载脂蛋白A-I作为脂多糖进入大鼠肝细胞的载体。
Apolipoprotein A-I as a carrier of lipopolysaccharide into rat hepatocytes.
作者信息
Sumenkova D V, Polyakov L M, Panin L E
机构信息
Research Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
出版信息
Bull Exp Biol Med. 2013 Oct;155(6):738-40. doi: 10.1007/s10517-013-2240-z.
Apolipoprotein A-I-mediated transport of LPS into isolated rat hepatocytes was demonstrated by means of fluorescent microscopy and spectrofluorometry. The efficiency of intracellular endotoxin transport in a complex with apolipoprotein A-I significantly exceeded the absorption of LPS without this carrier. Our results suggest that the mechanism of the anti-inflammatory effect of HDL and apolipoprotein A-I can be related to alternative pathway for metabolic degradation of this endotoxin with the involvement of lipoprotein receptors.
通过荧光显微镜和荧光分光光度法证实了载脂蛋白A-I介导脂多糖转运至分离的大鼠肝细胞内。载脂蛋白A-I复合物介导的细胞内内毒素转运效率显著超过无此载体时脂多糖的吸收效率。我们的结果表明，高密度脂蛋白和载脂蛋白A-I的抗炎作用机制可能与脂蛋白受体参与的内毒素代谢降解替代途径有关。
Zotero 插件