Proshchina A E, Savel'yev S V
Research Institute of Human Morphology, the Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2013 Oct;155(6):798-801. doi: 10.1007/s10517-013-2255-5.
Various types of insulin- and glucagon-containing endocrine cell distribution were found by double staining with antibodies to insulin and glucagon in the pancreatic autopsy material from subjects without carbohydrate metabolism disorders. The cell composition of the islets and their morphogenetic maturity depended on the vascularization degree. Insulin-containing cells predominated in small clusters of endocrine cells and in islets with few capillaries, while glucagon predominated in large islets with rich vascularization. A scheme of development and differentiation of Langerhans islets in the adult human pancreas was presented.
在无碳水化合物代谢紊乱受试者的胰腺尸检材料中，通过胰岛素和胰高血糖素抗体双重染色发现了各种类型含胰岛素和胰高血糖素的内分泌细胞分布。胰岛的细胞组成及其形态发生成熟度取决于血管化程度。含胰岛素的细胞在小的内分泌细胞簇和毛细血管较少的胰岛中占主导地位，而胰高血糖素在血管丰富的大胰岛中占主导地位。本文提出了成人胰腺中朗格汉斯胰岛的发育和分化模式。
