Tan Pei-Xin, Du Sha-Sha, Ren Chen, Yao Qi-Wei, Yuan Ya-Wei
Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China E-mail :
Asian Pac J Cancer Prev. 2013;14(10):5631-5. doi: 10.7314/apjcp.2013.14.10.5631.
Cochlea hair cell death is regarded to be responsible for the radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers. In this mini- review, we focus on the current progresses trying to unravel mechanisms of radiation-induced hair cell death and find out possible protection. P53, reactive oxygen species (ROS) and c-Jun N-terminal kinase (JNK) pathways have been proposed as pivotal in the processes leading to radiation hair cell death. Potential protectants, such as amifostine, N-acetylcysteine (NAC) and epicatechin (EC) , are claimed to be effective at reducing radiation- inducedhair cell death. The RT dosage, selection and application of concurrent chemotherapy should be pre- examined in order to minimize the damage to cochlea hair cells.
耳蜗毛细胞死亡被认为是导致放射性感音神经性听力损失（SNHL）的原因，而SNHL是头颈癌放射治疗（RT）的主要并发症之一。在本综述中，我们聚焦于当前试图揭示辐射诱导毛细胞死亡机制并寻找可能保护措施的研究进展。P53、活性氧（ROS）和c-Jun氨基末端激酶（JNK）通路被认为在导致辐射性毛细胞死亡的过程中起关键作用。一些潜在的保护剂，如氨磷汀、N-乙酰半胱氨酸（NAC）和表儿茶素（EC），据称可有效减少辐射诱导的毛细胞死亡。为了将对耳蜗毛细胞的损伤降至最低，应预先检查放疗剂量、同步化疗的选择和应用。
