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DISC1 Ser704Cys 变异体的单体型分析在日本自杀完成者中的应用。

Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers.

机构信息

Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.

Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.

出版信息

Psychiatry Res. 2014 Jan 30;215(1):249-51. doi: 10.1016/j.psychres.2013.11.007. Epub 2013 Nov 16.

DOI:10.1016/j.psychres.2013.11.007
PMID:24289909
Abstract

The present study investigated the genetic association of the disrupted-in-schizophrenia 1 (DISC1) gene with suicide using 398 Japanese completed suicides and 511 healthy controls. The functional Ser704Cys variant of DISC1 was nominally associated with completed suicide. Enhanced evidence of association was observed in a multi-marker sliding window haplotype analysis (the lowest p=0.002). These findings warrant further studies with a larger sample size to confirm the association of DISC1 with suicide.

摘要

本研究使用 398 名日本完全自杀者和 511 名健康对照，调查了精神分裂症相关蛋白 1（DISC1）基因与自杀的遗传关联。DISC1 的功能变异 Ser704Cys 与完全自杀存在显著关联。在多标记滑动窗口单体型分析中观察到了更强的关联证据（最低 p=0.002）。这些发现需要更大的样本量进行进一步研究，以确认 DISC1 与自杀的关联。

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引用本文的文献

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Toward a biosignature for suicide.探寻自杀的生物标志物。
Am J Psychiatry. 2014 Dec 1;171(12):1259-77. doi: 10.1176/appi.ajp.2014.14020194. Epub 2014 Oct 31.
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An overview of the neurobiology of suicidal behaviors as one meta-system.自杀行为的神经生物学概述作为一个元系统。
Mol Psychiatry. 2015 Feb;20(1):56-71. doi: 10.1038/mp.2014.101. Epub 2014 Sep 2.