Program in Biological and Biomedical Sciences, University of Southern California, Los Angeles, California, USA; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
Int Rev Neurobiol. 2013;113:35-59. doi: 10.1016/B978-0-12-418700-9.00002-2.
Accumulating evidence indicates that long noncoding RNAs (lncRNAs) contribute to autism spectrum disorder (ASD) risk. Although a few lncRNAs have long been recognized to have important functions, the vast majority of this class of molecules remains uncharacterized. Because lncRNAs are more abundant in human brain than protein-coding RNAs, it is likely that they contribute to brain disorders, including ASD. We review here the known functions of lncRNAs and the potential contributions of lncRNAs to ASD.
越来越多的证据表明，长非编码 RNA（lncRNA）与自闭症谱系障碍（ASD）的风险有关。尽管有少数 lncRNA 早已被认为具有重要功能，但这一类分子的绝大多数仍未被描述。由于 lncRNA 在人类大脑中的丰度高于蛋白质编码 RNA，因此它们很可能对包括 ASD 在内的脑部疾病有贡献。我们在这里回顾了 lncRNA 的已知功能以及 lncRNA 对 ASD 的潜在贡献。
