长链非编码RNA（lncRNA）在细胞生物学、神经发育和神经疾病中的作用
Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders.
作者信息
Aliperti Vincenza, Skonieczna Justyna, Cerase Andrea
机构信息
Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
出版信息
Noncoding RNA. 2021 Jun 17;7(2):36. doi: 10.3390/ncrna7020036.
Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, neurodevelopmental and mental disorders. The identification and characterization of lncRNAs that are deregulated or mutated in neurodevelopmental and mental health diseases are fundamental to understanding the complex transcriptional processes in brain function. Crucially, lncRNAs can be exploited as a novel target for treating neurological disorders. In our review, we first summarize the recent advances in our understanding of lncRNA functions in the context of cell biology and then discussing their association with selected neuronal development and neurological disorders.
发育是一个复杂的过程，受遗传、表观遗传和环境线索的调控。最近，长链非编码RNA（lncRNAs）已成为包括大脑在内的多种组织中基因表达的关键调节因子。lncRNAs表达的改变与多种神经退行性疾病、神经发育疾病和精神疾病有关。鉴定和表征在神经发育和精神健康疾病中失调或突变的lncRNAs，对于理解大脑功能中复杂的转录过程至关重要。至关重要的是，lncRNAs可作为治疗神经系统疾病的新靶点。在我们的综述中，我们首先总结了在细胞生物学背景下对lncRNA功能理解的最新进展，然后讨论它们与特定神经元发育和神经系统疾病的关联。
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