Steinmann E, Pfisterer M, Burkart F
J Cardiovasc Pharmacol. 1986 Sep-Oct;8(5):1044-50. doi: 10.1097/00005344-198609000-00024.
To assess acute hemodynamic effects of the new beta-adrenergic blocking drug bisoprolol with experimentally documented beta 1 selectivity, we studied 16 patients with stable angina and angiographically proven coronary artery disease. Simultaneous right heart catheterization and radionuclide angiocardiography were performed at rest and during exercise without treatment (control) and 2 h after 5 mg bisoprolol (6 patients) and 20 mg bisoprolol (10 patients), respectively, administered perorally. The hemodynamic profile of bisoprolol was similar to that previously described after acute beta-blockade. A negative chronotropic effect occurred after 5 mg bisoprolol at rest, but the negative inotropic changes did not reach significance, whereas cardiac index decreased and total vascular resistance increased after 20 mg bisoprolol. During exercise, negative inotropic and blood-pressure-lowering effects were present after both dosages, resulting in improved myocardial oxygen consumption as reflected by a significantly reduced rate pressure product. Because ejection fraction and pulmonary capillary wedge pressure were not significantly changed even after the 20 mg dose, bisoprolol has only mild negative inotropic effects and seems hemodynamically safe.
为评估具有实验证明的β1选择性的新型β肾上腺素能阻滞剂比索洛尔的急性血流动力学效应，我们研究了16例稳定型心绞痛且经血管造影证实患有冠状动脉疾病的患者。在静息状态下以及运动期间未治疗（对照）时，以及分别口服5mg比索洛尔（6例患者）和20mg比索洛尔（10例患者）后2小时，同时进行右心导管检查和放射性核素心血管造影。比索洛尔的血流动力学特征与先前急性β受体阻滞剂治疗后所描述的相似。静息状态下服用5mg比索洛尔后出现负性变时效应，但负性变力性变化未达到显著水平，而服用20mg比索洛尔后心脏指数降低，总血管阻力增加。运动期间，两种剂量后均出现负性变力性和降压效应，导致心率血压乘积显著降低，反映出心肌耗氧量改善。因为即使在20mg剂量后射血分数和肺毛细血管楔压也没有显著变化，比索洛尔仅具有轻度负性变力性效应，且在血流动力学上似乎是安全的。
