Maisch B, Borst U, Gerhards W, Wagner G
Department of Internal Medicine - Cardiology, Philipps-University Marburg, Federal Republic of Germany.
Eur J Clin Pharmacol. 1989;36(3):217-22. doi: 10.1007/BF00558150.
The effects of 5 and 10 mg bisoprolol once daily for 7 days on exercise ECG, myocardial perfusion and left ventricular function in 25 patients with stable coronary heart disease have been assessed in a double-blind, randomized, parallel group trial design. ST-segment depression during exercise was reduced by 56% by 5 mg bisoprolol and by 64% after 10 mg; the difference between the dose levels was significant. Heart rate, systolic and diastolic blood pressure and the rate-pressure product were reduced to similar extent both at rest and during exercise by both doses. Left ventricular thallium-201 scintigrams indicated a significant reduction in myocardial perfusion defects after 10 mg bisoprolol compared to baseline; however, the difference between the two active treatments was not significant. Left atrial and left ventricular diameters obtained by one-dimensional echocardiography, and the calculated shortening fraction, remained unchanged after bisoprolol, and so gave no evidence of a negative inotropic action. It is concluded that 5 mg bisoprolol was effective in once-a-day treatment of angina pectoris due to coronary heart disease, and a further improvement can be expected on increasing the dose to 10 mg.
在一项双盲、随机、平行组试验设计中，评估了25例稳定型冠心病患者每日一次服用5毫克和10毫克比索洛尔，连续服用7天对运动心电图、心肌灌注和左心室功能的影响。5毫克比索洛尔可使运动期间的ST段压低降低56%，10毫克比索洛尔后降低64%；剂量水平之间的差异具有显著性。两种剂量在静息和运动时均能使心率、收缩压和舒张压以及心率-血压乘积降低到相似程度。左心室铊-201闪烁扫描显示，与基线相比，10毫克比索洛尔后心肌灌注缺损显著减少；然而，两种活性治疗之间的差异不显著。通过一维超声心动图获得的左心房和左心室直径以及计算得出的缩短分数，在服用比索洛尔后保持不变，因此没有证据表明有负性肌力作用。结论是，5毫克比索洛尔每日一次治疗冠心病所致心绞痛有效，将剂量增加到10毫克有望进一步改善。
