Dehghani Mohammad Reza, Majidi Nader, Rahmani Alireza, Asgari Behnam, Rezaei Yousef
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Cardiol J. 2014;21(5):492-9. doi: 10.5603/CJ.a2013.0154. Epub 2013 Dec 2.
Some evidences have shown the role of antioxidant vitamins in preventing atrial fibrillation (AF) after coronary artery bypass grafting (CABG) surgery. We sought to determine the effect of oral vitamin C on the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.
One-hundred patients who underwent isolated CABG surgery were prospectively assigned into two groups: Group 1 - 50 patients received 2 g of oral vitamin C before and 500 mg twice daily lasting for 5 days after surgery; Group 2 - 50 patients as the control group did not receive any. All patients were continuously monitored after surgery in the intensive careunit (ICU), and then Holter monitoring was implemented for 72 h.
The mean of patients' age was 61.31 ± 6.42 years. Postoperative AF occurred in 16 and 4 patients in control and treatment groups, respectively (32% vs. 8%, p = 0.003). The ICU stay was 1.79 ± 0.313 and 2.10 ± 0.61 days for vitamin C and control groups, respectively (p = 0.002). The hospital stay was significantly lower in vitamin C group compared with that of the control group (5.32 ± 0.59 vs. 5.74 ± 1.30 days, respectively, p = 0.041). Baseline erythrocyte sedimentation rate (OR 1.030, 95% CI 1.003-1.058, p = 0.030) and taking vitamin C (OR 8.068, 95% CI 1.783-36.517, p = 0.007) were the independent predictors of postoperative AF.
Oral vitamin C can be safely used to decrease the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.
一些证据表明抗氧化维生素在冠状动脉旁路移植术（CABG）后预防心房颤动（AF）方面的作用。我们试图确定口服维生素C对接受择期体外循环CABG手术患者术后AF发生率的影响。
100例行单纯CABG手术的患者被前瞻性地分为两组：第1组 - 50例患者在术前接受2g口服维生素C，术后每天两次，每次500mg，持续5天；第2组 - 50例患者作为对照组，未接受任何治疗。所有患者术后在重症监护病房（ICU）持续监测，然后进行72小时动态心电图监测。
患者的平均年龄为61.31±6.42岁。对照组和治疗组分别有16例和4例患者发生术后AF（32%对8%，p = 0.003）。维生素C组和对照组的ICU住院时间分别为1.79±0.313天和2.10±0.61天（p = 0.002）。维生素C组的住院时间明显低于对照组（分别为5.32±0.59天和5.74±1.30天，p = 0.041）。基线红细胞沉降率（OR 1.030，95%CI 1.003-1.058，p = 0.030）和服用维生素C（OR 8.068，95%CI 1.783-36.517，p = 0.007）是术后AF的独立预测因素。
口服维生素C可安全用于降低接受择期体外循环CABG手术患者术后AF的发生率。
