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[类风湿关节炎的甲周毛细血管镜检查。80例前瞻性研究]

[Periungual capillaroscopy in rheumatoid arthritis. Prospective study of 80 cases].

作者信息

Drevet J G, Carpentier P H, Lelong C, Juvin R, Franco A, Phelip X

出版信息

Rev Rhum Mal Osteoartic. 1986 Jun;53(6):367-71.

PMID:2429362
Abstract

This study involved the screening for dermal microcirculatory abnormalities using periungueal capillaroscopy in a group of 80 cases of rheumatoid arthritis, so-defined in terms of ARA criteria. Excessive erythrocyte aggregation and/or pericapillary edema were detected in 74% of cases and were statistically correlated with ESR, reflecting an inflammatory syndrome. Capillary neogenesis, probably in reaction to subclinical cutaneous vascularity, was detected in 59% of cases (86% of subjects presenting extra-articular rheumatism). In 28% of cases this was accompanied by spontaneous hemorrhage, suggesting a progressive condition. Stigmata of cutaneous atrophy were present in 54% of subjects. These findings demonstrate the frequency of subclinical cutaneous damage in rheumatoid disease and suggest the possibility of the clinical usefulness of capillaroscopy, a non-invasive technic, in the follow-up of this disease.

摘要

本研究对一组80例根据美国风湿病学会(ARA)标准定义的类风湿关节炎患者,采用甲周毛细血管镜检查筛选皮肤微循环异常情况。74%的病例检测到红细胞过度聚集和/或毛细血管周围水肿,且与血沉存在统计学相关性,反映出一种炎症综合征。59%的病例检测到毛细血管新生,可能是对亚临床皮肤血管状态的反应(86%有风湿性关节外表现的受试者出现此情况)。28%的病例伴有自发性出血,提示病情进展。54%的受试者存在皮肤萎缩迹象。这些发现表明类风湿病亚临床皮肤损害的发生率,并提示毛细血管镜检查这一非侵入性技术在该病随访中具有临床应用价值的可能性。

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