Zhou Qina, Hu Jialu, Guo Yujun, Zhang Feng, Yang Xi, Zhang Ling, Xu Xiaoxia, Wang Lingpeng, Wang Hongli, Hou Yuemei
Department of Arrhythmia, Cardiovascular Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;
Exp Clin Cardiol. 2013 Winter;18(1):38-42.
To investigate the effect of the stellate ganglion (SG) and its left-right asymmetry on atrial fibrillation (AF) inducibility, AF duration and atrial electrophysiological properties.
Sixteen adult mongrel dogs were randomly assigned to three groups. The control group (n=4) underwent 6 h rapid atrial pacing (RAP) only; the right SG (RSG) group (n=6) underwent 6 h RSG stimulation plus RAP; and the left SG (LSG) group (n=6) underwent 6 h LSG stimulation plus RAP. AF induction rate, AF duration, effective refractory period (ERP) and dispersion of ERP (dERP) were measured.
In the RSG group, the induction rate of AF was significantly increased in sites in the right atrium (RA) compared with baseline (P<0.05). In the LSG group, the induction rate of AF was significantly increased (P<0.05) compared with baseline in the left atrium (LA), left superior pulmonary vein and left inferior pulmonary vein, respectively. Compared with RSG stimulation, right stellate ganglionectomy markedly decreased the AF induction rate of the RA (P<0.05). Compared with LSG stimulation, left stellate ganglionectomy markedly decreased the AF induction rate of the LA, the left superior pulmonary vein and the left inferior pulmonary vein (P<0.05). In the RSG group, the ERP was significantly shortened (P<0.05) and the dERP was significantly increased (P<0.05) in RA sites (P<0.05). The ERP was significantly shortened in the LSG group (P<0.05). The dERP was significantly increased (P<0.05) in LA and pulmonary vein sites (P<0.05).
Unilateral electrical stimulation of the SG in combination with RAP can successfully establish a canine model of acute AF mediated by excessive sympathetic activity. SG stimulation facilitates AF induction and aggravates electrical remodelling in sites in the atrium and pulmonary vein. Inhibiting sympathetic nerve activation through unilateral stellate ganglionectomy can reduce AF initiation.
研究星状神经节（SG）及其左右不对称性对心房颤动（AF）诱发率、AF持续时间及心房电生理特性的影响。
将16只成年杂种犬随机分为三组。对照组（n = 4）仅进行6小时快速心房起搏（RAP）；右侧星状神经节（RSG）组（n = 6）进行6小时RSG刺激加RAP；左侧星状神经节（LSG）组（n = 6）进行6小时LSG刺激加RAP。测量AF诱发率、AF持续时间、有效不应期（ERP）及ERP离散度（dERP）。
在RSG组，右心房（RA）部位的AF诱发率较基线显著增加（P<0.05）。在LSG组，左心房（LA）、左上肺静脉和左下肺静脉的AF诱发率分别较基线显著增加（P<0.05）。与RSG刺激相比，右侧星状神经节切除术显著降低了RA的AF诱发率（P<0.05）。与LSG刺激相比，左侧星状神经节切除术显著降低了LA、左上肺静脉和左下肺静脉的AF诱发率（P<0.05）。在RSG组，RA部位的ERP显著缩短（P<0.05），dERP显著增加（P<0.05）。LSG组的ERP显著缩短（P<0.05）。LA和肺静脉部位的dERP显著增加（P<0.05）。
单侧SG电刺激联合RAP可成功建立由过度交感神经活动介导的犬急性AF模型。SG刺激促进AF诱发并加重心房和肺静脉部位的电重构。通过单侧星状神经节切除术抑制交感神经激活可降低AF的起始。
