电化学治疗作为头颈部晚期 Merkel 细胞癌的一种新的治疗策略。
Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.
机构信息
Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
出版信息
Radiol Oncol. 2013 Oct 8;47(4):366-9. doi: 10.2478/raon-2013-0059. eCollection 2013.
Abstract
BACKGROUND
Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.
CASE REPORT
We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.
CONCLUSIONS
Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.
摘要
背景
默克尔细胞癌（Merkel cell carcinoma，MCC）是一种罕见且侵袭性强的肿瘤，起源于位于表皮基底层的皮肤机械感受器细胞，预后不良。疾病初始阶段的治疗选择是手术和/或放疗。复发性或晚期疾病的治疗仍存在争议。
病例报告
我们报告了一例 84 岁女性，因下巴复发性 MCC 接受电化学疗法（ECT）治疗。在 20 个月期间，进行了四次 ECT 治疗，结果肿瘤客观缓解，残余生活质量良好。
结论
我们的病例表明，ECT 对不适合标准治疗方案的头颈部局部晚期 MCC 患者的治疗有效。
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