Unité de Recherche 03/UR/09-01 «Génome, Diagnostic Immunitaire et valorisation», Institut Supérieur de Biotechnologie de Monastir, Université de Monastir, Avenue Tahar Haddad, BP 74, 5000 Monastir, Tunisia.
Food Chem. 2014 Apr 15;149:271-6. doi: 10.1016/j.foodchem.2013.10.101. Epub 2013 Nov 1.
This study was carried out to determine the effect of dietary fibre (DF) of barley Rihane (BR) in the attenuation of colon, liver and lung histopathology alterations induced by azoxymethane (AOM) in rats. Rats were fed a control (C) or experimental diet containing 30% of BR. The intended rats for cancer treatment received two successive subcutaneous injections of azoxymethane (AOM) at 20mg/kg body weight. The colons were analyzed for crypt multiplicity after 12 weeks of treatment. A histological study of the colon, liver and lungs was determined. The results showed that the BR diet significantly reduced the number of aberrant crypt per focus and altered their distribution. In addition, DF of BR increased significantly the mucus secretion compared to control group. The use of the AOM as colon specific carcinogen substance altered the liver and lung architectures, whereas the presence of DF of BR could be a protective factor for these organs.
本研究旨在确定大麦 Rihane（BR）膳食纤维（DF）对氧化偶氮甲烷（AOM）诱导的大鼠结肠、肝脏和肺组织病理学改变的缓解作用。大鼠喂食对照（C）或含 30%BR 的实验饮食。接受癌症治疗的大鼠接受了两次连续的 20mg/kg 体重的皮下注射 AOM。在治疗 12 周后分析结肠隐窝倍数。对结肠、肝脏和肺进行组织学研究。结果表明，BR 饮食可显著降低异常隐窝数/焦点，并改变其分布。此外，与对照组相比，BR 的 DF 显著增加了粘液分泌。AOM 作为结肠特异性致癌物质的使用改变了肝脏和肺的结构，而 BR 的 DF 的存在可能是这些器官的保护因素。
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