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抗惊厥治疗会引发类似进行性系统性硬化症的疾病吗?(作者译)

[A progressive systemic sclerosis like disease due to anticonvulsive therapy? (author's transl)].

作者信息

Zangemeister W H, Weisner B

出版信息

Fortschr Neurol Psychiatr Grenzgeb. 1977 Sep;45(9):501-7.

PMID:242960
Abstract

Two cases are presented which have been treated anticonvulsively for many years - especially with Phenytoin and Mephenytoin. The clinical syndrom as well as the changes of the connective tissue show transitions of Progressive systemic sklerosis (PSS) to systemic Lupus Erythematodes (SLE) and Dermatomyositis. The correlation with the therapy is reflected in consideration of immunological phenomenons.

摘要

本文报告两例多年来接受抗惊厥治疗的病例,尤其是使用苯妥英钠和甲妥英。临床综合征以及结缔组织的变化显示出进行性系统性硬化症(PSS)向系统性红斑狼疮(SLE)和皮肌炎的转变。考虑到免疫学现象,体现了与治疗的相关性。

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