Mikrobiologisches Institut, Universitätsklinikum Erlangen, Erlangen, 91054, Germany.
Adv Exp Med Biol. 2011;715:17-34. doi: 10.1007/978-94-007-0940-9_2.
Salmonella enterica is an invasive, facultative intracellular pathogen of animal and man with the ability to colonize various niches in diverse host organisms. The pathogenesis of infections by S. enterica requires adhesion to various host cell surfaces, and a large number of adhesive structures can be found. Depending on the serotype of S. enterica, gene clusters for more than 10 different fimbrial adhesins were identified, with type I fimbriae such as Fim, Lpf (long polar fimbriae), Tafi (thin aggregative fimbriae) or the type IV pili of serotype Typhi. In addition, autotransporter adhesins such as ShdA, MisL and SadA and the type I secreted large repetitive adhesins SiiE and BapA have been identified. Although the functions of many of the various adhesins are not well understood, recent studies show the specific structural and functional properties of Salmonella adhesins and how they act in concert with other virulence determinants. In this chapter, we describe the molecular characteristics of Salmonella adhesins and link these features to their multiple functions in infection biology.
肠炎沙门氏菌是一种侵袭性、兼性细胞内病原体，能够在各种宿主生物的不同生态位中定殖。肠炎沙门氏菌感染的发病机制需要粘附到各种宿主细胞表面，并且可以发现大量的粘附结构。根据肠炎沙门氏菌的血清型，已经鉴定出了超过 10 种不同菌毛粘附素的基因簇，包括 Fim、Lpf（长极菌毛）、Tafi（薄聚集菌毛）或 Typhi 血清型的 IV 型菌毛。此外，还鉴定出了自转运体粘附素，如 ShdA、MisL 和 SadA，以及 I 型分泌的大型重复粘附素 SiiE 和 BapA。尽管许多不同粘附素的功能尚未得到很好的理解，但最近的研究表明，沙门氏菌粘附素具有特定的结构和功能特性，以及它们如何与其他毒力决定因素协同作用。在本章中，我们描述了沙门氏菌粘附素的分子特征，并将这些特征与其在感染生物学中的多种功能联系起来。
