Swiss Institute for Experimental Cancer Research (ISREC), Ecole Polytechnique Federale Lausanne (EPFL), Lausanne 1015, Switzerland.
Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a017772. doi: 10.1101/cshperspect.a017772.
The development and maintenance of the skin are dependent on myriad signaling pathways that regulate a variety of cellular processes. In cutaneous epithelial cells, the Notch cascade plays a central role in ensuring that proliferation and differentiation are coordinated appropriately, a function that it imparts during both ontogeny and homeostasis. Aberrations of the Notch signaling pathway result in severe abnormalities in the epidermis and its appendages and cause functional defects such as perturbed barrier function. In addition, impaired Notch signaling is associated with diseases of the skin such as atopy and cancer. The pathology associated with aberrant cutaneous Notch signaling reflects the complex mechanisms underpinning its function in this tissue and involves both cell-autonomous and nonautonomous mechanisms. This review summarizes our current knowledge of the role of Notch signaling in the skin during health and disease.
皮肤的发育和维持依赖于多种信号通路，这些通路调节着各种细胞过程。在皮肤上皮细胞中，Notch 级联反应在确保增殖和分化得到适当协调方面发挥着核心作用，这一功能在个体发生和体内平衡过程中都存在。Notch 信号通路的异常会导致表皮及其附属物严重异常，并导致功能缺陷，如屏障功能受损。此外，Notch 信号通路的损伤与皮肤疾病有关，如特应性皮炎和癌症。与异常皮肤 Notch 信号相关的病理学反映了其在该组织中功能的复杂机制，涉及自主和非自主机制。这篇综述总结了我们目前对 Notch 信号在健康和疾病皮肤中的作用的认识。
