Pankratova Maria D, Riabinin Andrei A, Butova Elizaveta A, Selivanovskiy Arseniy V, Morgun Elena I, Ulianov Sergey V, Vorotelyak Ekaterina A, Kalabusheva Ekaterina P
Cell Biology Laboratory, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Laboratory of Structural-Functional Organization of Chromosomes, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Int J Mol Sci. 2024 Nov 30;25(23):12903. doi: 10.3390/ijms252312903.
The paralogues Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) control cell proliferation and cell fate determination from embryogenesis to ageing. In the skin epidermis, these proteins are involved in both homeostatic cell renewal and injury-induced regeneration and also drive carcinogenesis and other pathologies. YAP and TAZ are usually considered downstream of the Hippo pathway. However, they are the central integrating link for the signalling microenvironment since they are involved in the interplay with signalling cascades induced by growth factors, cytokines, and physical parameters of the extracellular matrix. In this review, we summarise the evidence on how YAP and TAZ are activated in epidermal keratinocytes; how YAP/TAZ-mediated signalling cooperates with other signalling molecules at the plasma membrane, cytoplasmic, and nuclear levels; and how YAP/TAZ ultimately controls transcription programmes, defining epidermal cell fate.
同源蛋白Yes相关蛋白（YAP）和含PDZ结合基序的转录共激活因子（TAZ）控制着从胚胎发育到衰老过程中的细胞增殖和细胞命运决定。在皮肤表皮中，这些蛋白质参与稳态细胞更新和损伤诱导的再生，也驱动癌症发生和其他病理过程。YAP和TAZ通常被认为是Hippo信号通路的下游分子。然而，它们是信号微环境的核心整合环节，因为它们参与了与生长因子、细胞因子和细胞外基质物理参数诱导的信号级联的相互作用。在这篇综述中，我们总结了关于YAP和TAZ在表皮角质形成细胞中如何被激活；YAP/TAZ介导的信号在质膜、细胞质和细胞核水平如何与其他信号分子协同作用；以及YAP/TAZ最终如何控制转录程序以决定表皮细胞命运的证据。
