Pereira-da-Silva Tiago, Bernardes Luís, Cacela Duarte, Fiarresga António, Sousa Lídia, Patrício Lino, Ferreira Rui Cruz
Cardiology Department, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.
J Invasive Cardiol. 2013 Dec;25(12):666-9.
To evaluate the long-term clinical outcomes following percutaneous coronary intervention (PCI) with the Genous stent in an unselected population.
All patients admitted to a single center who underwent PCI using the GS exclusively, between May 2006 and May 2012, were enrolled, and a clinical follow-up of up to 60 months was carried out. The primary endpoint of major adverse cardiac event (MACE) rate was defined as the composite of cardiac death, acute myocardial infarction (AMI), and target lesion revascularization (TLR).
Of the 450 patients included (75.1% male; 65.5 ± 11.7 years), 28.4% were diabetic and acute coronary syndrome was the reason for PCI in 76.4%. Angioplasty was performed in 524 lesions using 597 Genous stents, with angiographic success in 97.1%. At a median of 36 months of follow-up (range, 1-75 months), MACE, AMI, TLR, stent restenosis (SR), and stent thrombosis (ST) rates were 15.6%, 8.4%, 4.4%, 3.8%, and 2.2%, respectively. Between 12 and 24 months, the TLR, SR, and ST rates practically stabilized, up to 60 months. Bifurcation lesions were independently associated with MACE, TLR, and SR.
This is the first study reporting clinical results with the Genous stent up to 60 months. The Genous stent was safe and effective in the long-term, in an unselected population.
评估在未经筛选的人群中使用吉威思支架进行经皮冠状动脉介入治疗（PCI）后的长期临床结局。
纳入2006年5月至2012年5月期间在单一中心仅使用吉威思支架进行PCI的所有患者，并进行长达60个月的临床随访。主要不良心脏事件（MACE）率的主要终点定义为心源性死亡、急性心肌梗死（AMI）和靶病变血运重建（TLR）的复合终点。
纳入的450例患者中（男性占75.1%；年龄65.5±11.7岁），28.4%为糖尿病患者，76.4%的患者因急性冠状动脉综合征接受PCI。使用597枚吉威思支架对524处病变进行了血管成形术，血管造影成功率为97.1%。在中位随访36个月（范围1 - 75个月）时，MACE、AMI、TLR、支架再狭窄（SR）和支架血栓形成（ST）率分别为15.6%、8.4%、4.4%、3.8%和2.2%。在12至24个月期间，TLR、SR和ST率基本稳定，直至60个月。分叉病变与MACE、TLR和SR独立相关。
这是第一项报告使用吉威思支架长达60个月临床结果的研究。在未经筛选的人群中，吉威思支架长期而言是安全有效的。
