脐血中嗜碱性粒细胞/IgE系统的功能评估

Functional evaluation of the basophil/IgE system in the cord blood.

作者信息

Miadonna A, Tedeschi A, Leggieri E, Motta G, Fabbri C, Froldi M, Agosti M, Lorini M, Marini A, Zanussi C

出版信息

Int Arch Allergy Appl Immunol. 1986;81(3):276-83. doi: 10.1159/000234147.

Abstract

Basophil releasability was studied in 24 cord blood samples from normal-term deliveries. The histamine content in cord blood basophils was similar to that of adult blood basophils. The response to IgE-independent degranulating stimuli such as calcium ionophore A23187 and zymosan-activated human serum was overlapping with that of normal adults. Conversely, a reduced releasability was observed after challenge with anti-IgE, even after sensitization with an IgE-rich serum. The IgE-dependent degranulation seems to be hampered by the low concentrations of circulating and cell-bound IgE antibodies. The number of IgE molecules bound to the specific receptors in cord blood basophils is significantly lower than in adult blood basophils.

摘要

对24份足月分娩的脐血样本进行了嗜碱性粒细胞释放能力的研究。脐血嗜碱性粒细胞中的组胺含量与成人血液嗜碱性粒细胞的相似。对钙离子载体A23187和酵母聚糖激活的人血清等不依赖IgE的脱颗粒刺激的反应与正常成年人的反应重叠。相反，即使在用富含IgE的血清致敏后，用抗IgE激发后仍观察到释放能力降低。依赖IgE的脱颗粒似乎受到循环中和细胞结合的IgE抗体低浓度的阻碍。脐血嗜碱性粒细胞中与特异性受体结合的IgE分子数量明显低于成人血液嗜碱性粒细胞。