Maxillo-Facial Surgery, Second University of Naples, Naples, Italy; University of Foggia, Foggia, Italy; Plastic Surgery, La Sapienza University, Rome, Italy.
Dermatol Surg. 2013 Dec;39(12):1887-94. doi: 10.1111/dsu.12358. Epub 2013 Nov 7.
Human immunodeficiency virus (HIV)-related facial lipoatrophy seems to be the most distressing manifestation for individuals with HIV. It can be stigmatizing, severely affecting quality of life and self-esteem. Ever-increasing numbers of individuals with HIV receiving medication for HIV infection are presenting to plastic surgeons and requesting reconstructive surgery to counteract the unwanted side effects of their treatment protocols, for example facial lipoatrophy. The authors show their results with a one-step rehabilitation in cases of facial lipoatrophy using an injectable calcium hydroxylapatite dermal filler mixed with local anesthetic and adrenaline.
This study was conducted as a clinical prospective study; 26 individuals with HIV receiving antiretroviral therapy and with facial lipoatrophy received injections of an injectable calcium hydroxylapatite dermal filler mixed with local anesthetic and adrenaline.
No major complications were registered. A stable result was observed in all the cases at the end of follow-up (3 months). High patient satisfaction was achieved in all cases.
The outcomes of this study confirm that calcium hydroxylapatite dermal filler safely and effectively ameliorates the appearance of patients with HIV-related facial lipoatrophy, and mixing it with local anaesthetic and adrenaline can reduce pain during injection and ecchymosis.
人类免疫缺陷病毒（HIV）相关的面部脂肪萎缩似乎是 HIV 感染者最令人痛苦的表现。它可能会带来耻辱感，严重影响生活质量和自尊心。越来越多的 HIV 感染者因 HIV 感染接受药物治疗，他们向整形医生寻求重建手术，以抵消治疗方案的不良副作用，例如面部脂肪萎缩。作者展示了他们使用可注射的羟基磷灰石钙真皮填充剂与局部麻醉剂和肾上腺素混合，对一例面部脂肪萎缩进行一步康复治疗的结果。
这是一项临床前瞻性研究；26 名接受抗逆转录病毒治疗且有面部脂肪萎缩的 HIV 感染者接受了可注射的羟基磷灰石钙真皮填充剂与局部麻醉剂和肾上腺素的注射。
未记录到重大并发症。在随访结束时（3 个月），所有病例均观察到稳定的结果。所有病例均获得了高患者满意度。
本研究的结果证实，羟基磷灰石钙真皮填充剂安全有效地改善了 HIV 相关面部脂肪萎缩患者的外观，将其与局部麻醉剂和肾上腺素混合使用可以减少注射过程中的疼痛和瘀伤。
