Centro Polispecialistico Santa Apollonia, S. Maria C. V. (CE), Italy.
Dermatol Surg. 2011 Nov;37(11):1584-9. doi: 10.1111/j.1524-4725.2011.02131.x. Epub 2011 Aug 1.
Lipoatrophy of the face affects the quality of life and body image of individuals receiving antiretroviral therapy. The objective of this study was to assess the safety and efficacy of a permanent nonbiodegradable polyacrylamide gel filler, used for facial wasting rehabilitation.
Thirty-two individuals positive for the human immunodeficiency virus (HIV) were enrolled in the study between January 2007 and January 2009 and treated using nonbiodegradable polyacrylamide gel injections for a facial wasting rehabilitation.
Local infection, foreign body reaction, and migration of the product were not observed during follow-up (18 months). Small, palpable, nonvisible nodules were recorded in 13 cases at the end of follow-up.
Polyacrylamide hydrogel is an appropriate treatment option in restoring facial contours in immunocompromised people with HIV. Injections of large volumes of polyacrylamide gel (8 to 12 mL) are not associated with a high rate of complications such as infection and foreign body reaction and allow improvement in quality of life in a limited time.
面部脂肪萎缩会影响接受抗逆转录病毒治疗的个体的生活质量和身体形象。本研究的目的是评估一种用于面部消瘦康复的永久性不可生物降解的聚丙烯酰胺凝胶填充物的安全性和疗效。
2007 年 1 月至 2009 年 1 月期间，32 名人类免疫缺陷病毒（HIV）阳性个体入组本研究，并接受不可生物降解的聚丙烯酰胺凝胶注射治疗以进行面部消瘦康复。
在随访（18 个月）期间未观察到局部感染、异物反应和产品迁移。在随访结束时，13 例记录到小的、可触及的、不可见的结节。
聚丙烯酰胺水凝胶是恢复 HIV 免疫功能低下者面部轮廓的一种合适的治疗选择。注射大体积的聚丙烯酰胺凝胶（8 至 12 毫升）不会导致感染和异物反应等并发症的高发生率，并能在有限的时间内改善生活质量。
