Srinivasan K G, Gaikwad A, Ushanandhini K P, Ritesh K
K G S Scans, Anna Nagar; Maduri, India -
Neuroradiol J. 2007 Jun 30;20(3):373-6. doi: 10.1177/197140090702000322.
The most serious complication of Paget's disease is sarcomatous degeneration of pagetic bone. Multifocal sarcomatous degeneration occurs mainly in polyostotic Paget's disease. Paget sarcomas are the most threatening sarcomas of bone irrespective of the histopathology, their prognosis being far more negative than primary sarcomas. Paget's disease is a common entity but osteosarcoma arising in Paget's disease is an infrequent complication. The skull involvement is even rarer. We report a case of malignant transformation of a skull lesion in a patient of polyostotic Paget's disease. Skull radiographs, computed tomography and magnetic resonance imaging scans of the tumour area show interesting results.
佩吉特病最严重的并发症是佩吉特骨的肉瘤样变性。多灶性肉瘤样变性主要发生在多骨型佩吉特病中。佩吉特肉瘤是最具威胁性的骨肉瘤，无论其组织病理学如何，其预后比原发性肉瘤要差得多。佩吉特病是一种常见病症，但由佩吉特病引发的骨肉瘤是一种罕见的并发症。颅骨受累更为罕见。我们报告一例多骨型佩吉特病患者颅骨病变发生恶性转化的病例。肿瘤区域的颅骨X线片、计算机断层扫描和磁共振成像扫描显示出有趣的结果。
