Huanhu Hospital, Tianjin 300060, PR China.
Carbohydr Polym. 2014 Jan 30;101:171-8. doi: 10.1016/j.carbpol.2013.09.001. Epub 2013 Sep 5.
Thermosensitive methyl cellulose (MC)-based injectable hydrogels for post-operation anti-adhesion were prepared by integrating polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and chitosan sulfate (CS-SO3) with MC sols. The viscosity of the MC-based sols depended on the sol composition, especially the amount of CMC. The gelation temperature of the sols was tuned by adjusting the concentrations of K(+) and other components to obtain an MC-based sol that transformed to a gel at body temperature. The composition of the sol also affected the gel strength. Adding PEG decreased the repulsions between the CMC and CS-SO3 macromolecules and thus increased the gel strength. The efficacy of the MC-based injectable hydrogels as barriers for reducing postsurgical adhesions was evaluated using a rat cecal abrasion model. The PEG and CS-SO3 loaded MC-based injectable hydrogels were effective in reducing adhesion formation and reduced adhesiolysis difficulties.
聚乙二醇（PEG）、羧甲基纤维素（CMC）和壳聚糖硫酸酯（CS-SO3）与 MC 溶胶结合，制备了用于术后防粘连的温敏甲基纤维素（MC）基可注射水凝胶。MC 基溶胶的粘度取决于溶胶的组成，特别是 CMC 的用量。通过调整 K（+）和其他成分的浓度来调节溶胶的胶凝温度，以获得一种在体温下转变为凝胶的 MC 基溶胶。溶胶的组成也会影响凝胶的强度。添加 PEG 降低了 CMC 和 CS-SO3 大分子之间的排斥力，从而提高了凝胶的强度。使用大鼠盲肠磨损模型评估了 MC 基可注射水凝胶作为减少术后粘连的屏障的功效。PEG 和 CS-SO3 负载的 MC 基可注射水凝胶可有效减少粘连形成，并降低粘连松解的难度。
