Lin Qi-chang, Xie Han-sheng, Liu Xue-jun, Zhou Jin-ling, Zhao Jian-ming
Department of Pneumology, First Affiliated Hospital, Fujian Medical University, Laboratory of Pneumology Fujian Medical University, Fuzhou 350005, China. Email:
Zhonghua Yi Xue Za Zhi. 2013 Aug 13;93(30):2355-8.
To evaluate the relationship between high sensitivity C-reactive protein (hs-CRP) level and the severity of obstructive sleep apnea-hypopnea syndrome (OSAHS) in non-obese patients.
A total of 65 patients with suspected OSAHS were recruited. Those with a history of cardiovascular or cerebrovascular events, arterial hypertension, chronic obstructive pulmonary disease, diabetes mellitus and smoking were excluded. All subjects were examined by polysomnography. Subjects with an apnea-hypopnea index (AHI) ≥ 5 were considered to have OSAHS. They were divided into mild, moderate and severe OSAHS groups and those with an AHI < 5 were accepted into the control group. The serum level of hs-CRP, a biomarker for cardiovascular disease, was measured with peripheral venous blood samples.
There were 53 males and 12 females with a mean age 44.3 ± 12.2 years and a body mass index (BMI) <25 kg/m(2). The serum levels of hs-CRP were significantly higher in OSAHS patients than those of the controls (geometric mean [95% confidence interval] 0.416 [0.288-0.600] vs 0.749 [0.559-1.003] mg/L, P < 0.05). Mean levels of hs-CRP did not differ between the group with mild-to-moderate OSAHS and the control group. However, the severe OSAHS group had a higher level of hs-CRP than the control group (P = 0.004). A significant positive relationship existed between hs-CRP and AHI (r = 0.407, P = 0.001) . According to stepwise multivariate analysis, only AHI was a reliable predictor for elevated serum level of hs-CRP among all these related factors (R(2) = 0.166, P = 0.001).
The severity of OSAHS is associated with an elevated serum level of hs-CRP in non-obese patients.
评估非肥胖患者中高敏C反应蛋白（hs-CRP）水平与阻塞性睡眠呼吸暂停低通气综合征（OSAHS）严重程度之间的关系。
共招募了65例疑似OSAHS患者。排除有心血管或脑血管事件、动脉高血压、慢性阻塞性肺疾病、糖尿病病史及吸烟史的患者。所有受试者均接受多导睡眠图检查。呼吸暂停低通气指数（AHI）≥5的受试者被认为患有OSAHS。他们被分为轻度、中度和重度OSAHS组，AHI<5的受试者被纳入对照组。采用外周静脉血样本检测心血管疾病生物标志物hs-CRP的血清水平。
共有53例男性和12例女性，平均年龄44.3±12.2岁，体重指数（BMI）<25kg/m²。OSAHS患者的hs-CRP血清水平显著高于对照组（几何平均数[95%置信区间]0.416[0.288 - 0.600] vs 0.749[0.559 - 1.003]mg/L，P<0.05）。轻度至中度OSAHS组与对照组的hs-CRP平均水平无差异。然而，重度OSAHS组的hs-CRP水平高于对照组（P = 0.004）。hs-CRP与AHI之间存在显著正相关（r = 0.407，P = 0.001）。根据逐步多因素分析，在所有这些相关因素中，只有AHI是血清hs-CRP水平升高的可靠预测指标（R² = 0.166，P = 0.001）。
在非肥胖患者中，OSAHS的严重程度与血清hs-CRP水平升高有关。
