糠酸莫米松鼻喷雾剂辅助阿莫西林治疗儿童急性鼻窦炎的随机对照研究。
Fluticasone nasal spray as an adjunct to Amoxicillin for acute sinusitis in children: a randomized controlled trial.
机构信息
Department of Pediatrics, Department of ENT, Hormozgan University of Medical Sciences, Bandarabas, Iran.
出版信息
Eur Rev Med Pharmacol Sci. 2013 Nov;17(22):3068-72.
BACKGROUND
Approximately 0.5-2% of upper respiratory tract infections in adults and 6-13% of viral upper respiratory tract infections in children are complicated by acute sinusitis. This study was aimed to evaluate the coadministration effect of fluticasone nasal spray (FNS) with amoxicillin for AS in children.
MATERIALS AND METHODS
One hundred children 2 to 14 years of age with acute sinusitis referred to Shahid Mohammadi Pediatric Hospital in Bandar Abbas were randomly allocated into two equal intervention and control groups to receive amoxicillin with fluticasone nasal spray one puff twice daily for 14 days and amoxicillin 80 to 100 mg/kg/ day for 14 days respectively.
RESULTS
Twenty one (42%) of children in intervention group were cured completely and 2 (4%) children in control group had complete recovery (p < 0.001). Symptom severity score was 22.98 ± 2.95 before treatment that reduced to 13.26 ± 3.20 after treatment (p < 0.001).
CONCLUSIONS
Use of fluticasone can reduce the severity of symptoms of sinusitis in children.
背景
成人上呼吸道感染的 0.5-2%和约儿童病毒性上呼吸道感染的 6-13%会并发急性鼻窦炎。本研究旨在评估氟替卡松鼻喷雾剂（FNS）与阿莫西林联合治疗儿童急性鼻窦炎的效果。
材料与方法
100 名年龄在 2 至 14 岁的急性鼻窦炎患儿被随机分配到两组，干预组接受氟替卡松鼻喷雾剂一次一喷，每日两次，共 14 天，同时接受阿莫西林治疗；对照组接受阿莫西林 80-100mg/kg/天，共 14 天。
结果
干预组 21 名（42%）患儿完全治愈，对照组 2 名（4%）患儿完全康复（p<0.001）。治疗前症状严重程度评分为 22.98±2.95，治疗后降至 13.26±3.20（p<0.001）。
结论
使用氟替卡松可以减轻儿童鼻窦炎的症状严重程度。
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