Docherty R J, Brown D A
Neurosci Lett. 1986 Sep 25;70(1):110-5. doi: 10.1016/0304-3940(86)90447-7.
Two distinct Ca currents may be recorded from guinea pig hippocampal CA1 neuronal somata: a non-inactivating (persistent) current and a rapidly inactivating (transient) current. Nimodipine, a 'calcium antagonist', reduced both Ca currents though the transient current was somewhat less sensitive than the persistent current. BAY K 8644, a 'calcium agonist' enhanced the persistent current and shifted the activation threshold for this current to more negative potentials. BAY K 8644 also enhanced the transient Ca current though the effect was very variable. The results demonstrate that Ca channels in hippocampal CA1 neurones possess a dihydropyridine receptor in common with Ca channels in other tissues.
从豚鼠海马CA1神经元胞体可记录到两种不同的钙电流：一种非失活（持续）电流和一种快速失活（瞬态）电流。“钙拮抗剂”尼莫地平降低了两种钙电流，不过瞬态电流比持续电流的敏感性略低。“钙激动剂”BAY K 8644增强了持续电流，并将该电流的激活阈值移向更负的电位。BAY K 8644也增强了瞬态钙电流，不过其效果变化很大。结果表明，海马CA1神经元中的钙通道与其他组织中的钙通道一样，都具有二氢吡啶受体。
