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Excitatory action of BAYK8644 on hippocampal pyramidal neurones of the guinea pig in vitro.

作者信息

Docherty R J, Brown D A

出版信息

Neurosci Lett. 1986 Oct 8;70(2):239-44. doi: 10.1016/0304-3940(86)90470-2.

DOI:10.1016/0304-3940(86)90470-2
PMID:2430239
Abstract

BAYK8944, a calcium 'agonist' caused a slow depolarization of a proportion of CA1 hippocampal pyramidal cells and increased their input resistance. In voltage-clamped CA1 neurones BAYK8644 caused a decrease in depolarization-activated outward current. Reduction of depolarization-activated outward current was also produced by the Ca ionophore A23187. It is proposed that BAYK8644 and A23187 may cause suppression of outward current secondary to a prolonged increase in cytosolic Ca activity.

摘要

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引用本文的文献

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2
The effects of chronic treatment with the dihydropyridine, Bay K 8644, on hyperexcitability due to ethanol withdrawal, in vivo and in vitro.二氢吡啶类药物Bay K 8644长期治疗对乙醇戒断所致的体内外兴奋性过高的影响。
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