Andreasson L, Biörklund A, Mercke C, Scheike O, Andersson T, Brismar J, Elner A, Hellekant C, Landberg T, Tropé C
Radiother Oncol. 1986 Sep;7(1):37-45. doi: 10.1016/s0167-8140(86)80123-2.
Fifty-six patients with previously untreated, unresectable squamous cell carcinomas of the head and neck region were treated with repeated intra-arterial chemotherapy with mitomycin C using a selective or super-selective angiographic technique, and bleomycin given i.v., followed by radical radiotherapy. In addition, restricted tumour-reductive surgery was done in 18 of these patients. The response rate (CR + PR) after completion of the integrated treatment was 89%, with 63% of the patients showing CR. The toxicity of this regimen was, however, far from negligible. The median survival for this series of patients with advanced head and neck cancers is 19 months, and 17 are still alive after 16 + -66 + months.
56例先前未经治疗且无法切除的头颈部鳞状细胞癌患者，采用选择性或超选择性血管造影技术，接受丝裂霉素C重复动脉内化疗，并静脉注射博来霉素，随后进行根治性放疗。此外，其中18例患者接受了局限性肿瘤减积手术。综合治疗完成后的缓解率（完全缓解+部分缓解）为89%，63%的患者达到完全缓解。然而，该治疗方案的毒性不容小觑。这组晚期头颈部癌患者的中位生存期为19个月，17例患者在16±66个月后仍存活。
