Kapp A, Schöpf E
Acta Derm Venereol. 1986;66(4):285-9.
Polymorphonuclear leukocytes (PMN) of patients suffering from psoriasis and atopic dermatitis are supposed to differ in their function from the PMN of normals. However, conflicting results have been reported. Using a lucigenin-dependent chemiluminescence we investigated the response of isolated PMN from patients with atopic dermatitis (AD) and psoriasis to different stimuli. PMN of 17 patients with psoriasis and 13 patients with AD with mild to moderate disease activity were stimulated with a chemotactic peptide (f-met-phe), zymosan activated serum (ZAS), zymosan particles and phorbol myristate acetate. In the AD group we found a significantly decreased response after stimulation with ZAS in comparison to the controls. With the other stimuli tested no significant difference was detected. In comparison to normal controls psoriatic PMN showed no significant difference with any of the stimuli. Comparing patients with plaque-type and guttate-type psoriasis no significant difference was detected. We suggest that the reported hyperactivation of psoriatic PMN could be triggered by serum factors which were excluded in the present investigation. The decreased response of PMN to stimulation with ZAS from patients with AD associated with a normal reactivity to the other stimuli could be due to specific desensitization of the PMN by C5a in vivo.
银屑病和特应性皮炎患者的多形核白细胞（PMN）在功能上被认为与正常人的PMN不同。然而，已有相互矛盾的结果报道。我们使用基于光泽精的化学发光法，研究了来自特应性皮炎（AD）和银屑病患者的分离PMN对不同刺激的反应。用趋化肽（f-甲硫-苯丙氨酸）、酵母聚糖激活血清（ZAS）、酵母聚糖颗粒和佛波酯刺激17例银屑病患者和13例疾病活动度为轻度至中度的AD患者的PMN。在AD组中，与对照组相比，用ZAS刺激后反应显著降低。对于其他测试刺激，未检测到显著差异。与正常对照组相比，银屑病PMN对任何刺激均无显著差异。比较斑块型和点滴型银屑病患者，未检测到显著差异。我们认为，所报道的银屑病PMN的过度激活可能由血清因子触发，而本研究排除了这些血清因子。AD患者的PMN对ZAS刺激反应降低，而对其他刺激反应正常，这可能是由于体内C5a对PMN的特异性脱敏作用。
