Coble B I, Dahlgren C, Molin L, Stendahl O
Department of Dermatology, Linköping University Medical School, Sweden.
Acta Derm Venereol. 1987;67(6):481-90.
The present investigation focused on the oxidative response of polymorphonuclear neutrophil leukocytes in psoriasis, in particular pustular psoriasis and how this response was affected by different retinoid compounds. In the active phase of pustular psoriasis, the neutrophil chemiluminescence response to the chemotactic peptide f-met-leu-phe and to phorbol myristate acetate was enhanced and correlated to the development of pustules, whereas cells from psoriasis vulgaris patients showed normal chemiluminescence response. Retinoids, particularly tretinoin (= retinoic acid) and isotretinoin caused a pronounced inhibition of the chemiluminescence response only in primed neutrophils in vivo and in vitro, whereas etretinate and the metabolite Ro 10-1670 was less inhibitory. Retinoic acid furthermore inhibited the Fc-mediated phagocytosis, but did not affect C3bi-mediated phagocytosis. These data suggest that the antiinflammatory effect of retinoids may operate by affecting neutrophil activation and function.
本研究聚焦于银屑病，尤其是脓疱型银屑病中多形核中性粒细胞的氧化反应，以及这种反应如何受到不同类视黄醇化合物的影响。在脓疱型银屑病的活动期，中性粒细胞对趋化肽f-甲硫-亮-苯丙氨酸和佛波酯肉豆蔻酸酯乙酸盐的化学发光反应增强，且与脓疱的形成相关，而寻常型银屑病患者的细胞显示出正常的化学发光反应。类视黄醇，特别是维甲酸（=视黄酸）和异维甲酸，仅在体内和体外对已致敏的中性粒细胞的化学发光反应有明显抑制作用，而阿维A酯及其代谢产物Ro 10 - 1670的抑制作用较小。视黄酸还抑制Fc介导的吞噬作用，但不影响C3bi介导的吞噬作用。这些数据表明，类视黄醇的抗炎作用可能通过影响中性粒细胞的激活和功能来发挥。
