Department of Pharmacology and Department of Biomedical Science, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
J Physiol Pharmacol. 2013 Oct;64(5):531-4.
Sirtuin7 (SIRT7) is a NAD(+)-dependent protein deacetylase which belongs to sirtuin family. Although sirtuin proteins have attracted a great deal of attention, little is known about SIRT7. SIRT7 participates in rDNA transcription in the nucleolus. However, recent reports show that SIRT7 has additional novel functions. This review summarizes all findings about SIRT7, and highlights its critical roles in cellular functions.
Sirtuin7 (SIRT7) 是一种依赖 NAD(+)的蛋白去乙酰化酶，属于 sirtuin 家族。尽管 sirtuin 蛋白引起了广泛关注，但对 SIRT7 的了解甚少。SIRT7 参与核仁中的 rDNA 转录。然而，最近的报道表明 SIRT7 具有其他新的功能。本综述总结了关于 SIRT7 的所有发现，并强调了其在细胞功能中的关键作用。
