Blank Maximilian F, Grummt Ingrid
a Molecular Biology of the Cell II , German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance , Heidelberg , Germany.
Transcription. 2017 Mar 15;8(2):67-74. doi: 10.1080/21541264.2016.1276658. Epub 2017 Jan 9.
SIRT7, a member of the sirtuin family of NAD-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress resistance, aging and tumorigenesis. Despite this important functional link, the enzymatic activity, the molecular targets and physiological functions of SIRT7 are poorly defined. Here, we review recent progress in SIRT7 research and elaborate the main pathways in which SIRT7 participates.
SIRT7是烟酰胺腺嘌呤二核苷酸（NAD）依赖性蛋白质脱乙酰酶家族sirtuin的成员之一，是许多细胞活动的关键调节因子。SIRT7的表达与细胞增殖和致癌活性相关，将核糖体生物合成的SIRT7依赖性调节与控制细胞周期进程、代谢稳态、应激抗性、衰老和肿瘤发生的检查点联系起来。尽管存在这种重要的功能联系，但SIRT7的酶活性、分子靶点和生理功能仍不清楚。在此，我们综述了SIRT7研究的最新进展，并阐述了SIRT7参与的主要途径。
