Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan, Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan, Department of Computer Science and Engineering, National Chung Hsing University, Taichung 402, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan, Molecular Bioinformatics Center, National Chiao Tung University, Hsinchu 300, Taiwan, Graduate Department of Clinical Pharmacy, Taipei Medical University, Taipei 110, Taiwan, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 300, Taiwan, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan, Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu 300, Taiwan, Mackay Medicine, Nursing and Management College, Taipei 112, Taiwan, Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan, and Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Nucleic Acids Res. 2014 Jan;42(Database issue):D78-85. doi: 10.1093/nar/gkt1266. Epub 2013 Dec 4.
MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.
MicroRNAs (miRNAs) 是一类能够负调控基因表达从而控制许多细胞机制的小非编码 RNA 分子。miRTarBase 数据库（http://mirtarbase.mbc.nctu.edu.tw/）提供了经过实验验证的 miRNA 靶标相互作用的最新和最全面的信息。该数据库于 2010 年推出，其数据来源包括 100 多项关于 miRNA 靶标鉴定、miRNA 靶标分子网络和系统生物学的已发表研究，当前版本（2013 年，第 4 版）与最初版本（2010 年，第 1 版）相比有显著的扩展和增强。本文报告了数据库的当前状态和最近的改进，包括 (i) miRNA-靶标相互作用条目增加了 14 倍，(ii) miRNA-靶标网络，(iii) miRNA 和其靶基因的表达谱，(iv) miRNA 靶标相关疾病，以及 (v) 其他实用功能，包括升级提醒和错误报告/用户反馈系统。
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