Xiao Feifei, Zuo Zhixiang, Cai Guoshuai, Kang Shuli, Gao Xiaolian, Li Tongbin
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Nucleic Acids Res. 2009 Jan;37(Database issue):D105-10. doi: 10.1093/nar/gkn851. Epub 2008 Nov 7.
MicroRNAs (miRNAs) are an important class of small noncoding RNAs capable of regulating other genes' expression. Much progress has been made in computational target prediction of miRNAs in recent years. More than 10 miRNA target prediction programs have been established, yet, the prediction of animal miRNA targets remains a challenging task. We have developed miRecords, an integrated resource for animal miRNA-target interactions. The Validated Targets component of this resource hosts a large, high-quality manually curated database of experimentally validated miRNA-target interactions with systematic documentation of experimental support for each interaction. The current release of this database includes 1135 records of validated miRNA-target interactions between 301 miRNAs and 902 target genes in seven animal species. The Predicted Targets component of miRecords stores predicted miRNA targets produced by 11 established miRNA target prediction programs. miRecords is expected to serve as a useful resource not only for experimental miRNA researchers, but also for informatics scientists developing the next-generation miRNA target prediction programs. The miRecords is available at http://miRecords.umn.edu/miRecords.
微小RNA（miRNA）是一类重要的小型非编码RNA，能够调控其他基因的表达。近年来，miRNA的计算靶标预测取得了很大进展。已经建立了10多个miRNA靶标预测程序，然而，动物miRNA靶标的预测仍然是一项具有挑战性的任务。我们开发了miRecords，这是一个动物miRNA-靶标相互作用的综合资源库。该资源库的“验证靶标”组件拥有一个大型、高质量的人工整理数据库，其中包含经过实验验证的miRNA-靶标相互作用，并对每个相互作用的实验支持进行了系统记录。该数据库的当前版本包括7种动物物种中301个miRNA与902个靶基因之间1135条经过验证的miRNA-靶标相互作用记录。miRecords的“预测靶标”组件存储了由11个已建立的miRNA靶标预测程序产生的预测miRNA靶标。miRecords有望不仅为从事miRNA实验研究的人员，也为开发下一代miRNA靶标预测程序的信息学科学家提供有用的资源。可通过http://miRecords.umn.edu/miRecords访问miRecords。
