Chatani Megumi, Nakagawa Ichiro, Yamada Shuichi, Sugimoto Tadashi, Hironaka Yasuo, Nakamura Mitsutoshi, Nakase Hiroyuki
Department of Neurosurgery, Nara Medical University.
Neurol Med Chir (Tokyo). 2014;54(8):670-2. doi: 10.2176/nmc.cr2013-0061. Epub 2013 Dec 5.
Intracranial meningioma with intratumor metastasis have been occasionally reported. However, to our knowledge, there are almost no reports of malignant tumors initially discovered due to metastasis to meningioma. A 74-year-old woman presented with amnesia. Magnetic resonance imaging showed a well-defined mass arising from falcotentorial junction and homogeneous enhancement. Histopathologic findings showed that the mass was a meningothelial meningioma, with the majority of the tumor cells propagating in sheets, however, a single area in the tumor tissue showed the different histology. Immunohistologically, cytokeratin 7 (CK7), thyroid transcription factor-1 (TTF-1), and Napsin were positive, which led to lung adenocarcinoma metastasis. Furthermore, E-cadherin staining showed a 70% positive rate in lung adenocarcinoma and 30% in meningothelial meningioma. We report our experiences regarding a case of lung cancer that metastasized to intracranial meningioma and its clinical presentation and pathology.
颅内脑膜瘤伴瘤内转移偶有报道。然而，据我们所知，几乎没有因转移至脑膜瘤而最初被发现的恶性肿瘤的报道。一名74岁女性出现失忆症状。磁共振成像显示在小脑幕切迹处有一个边界清晰的肿块，呈均匀强化。组织病理学检查结果显示该肿块为脑膜内皮型脑膜瘤，大多数肿瘤细胞呈片状增殖，然而，肿瘤组织中的一个区域显示出不同的组织学特征。免疫组织化学检查显示，细胞角蛋白7（CK7）、甲状腺转录因子-1（TTF-1）和Napsin呈阳性，提示为肺腺癌转移。此外，E-钙黏蛋白染色显示肺腺癌的阳性率为70%，脑膜内皮型脑膜瘤的阳性率为30%。我们报告了一例肺癌转移至颅内脑膜瘤的病例及其临床表现和病理学情况。
