Gooderham Melinda
Skin Centre for Dermatology, Peterborough, ON, Canada.
Skin Therapy Lett. 2013 Nov-Dec;18(7):1-4.
Psoriasis is a chronic condition which requires ongoing management with therapies that have demonstrated favorable safety and efficacy profiles in long-term use. While biologics changed the way psoriasis is treated by providing effective targeted therapy, they are not without limitations. However, small molecules are emerging therapeutic options for the treatment of psoriasis. Several oral and topical small molecules, spanning different therapeutic classes, are proving to be promising treatment options in psoriasis. While studies to date have yielded positive results, further investigation of these agents are warranted for both safety and efficacy.
银屑病是一种慢性疾病，需要采用长期使用已证明具有良好安全性和有效性的疗法进行持续管理。虽然生物制剂通过提供有效的靶向治疗改变了银屑病的治疗方式，但它们并非没有局限性。然而，小分子药物正在成为治疗银屑病的新兴治疗选择。几种口服和外用的小分子药物，涵盖不同的治疗类别，在银屑病治疗中被证明是有前景的治疗选择。虽然迄今为止的研究已取得积极成果，但仍有必要对这些药物的安全性和有效性进行进一步研究。
