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揭开银屑病的面纱:深入探讨发病机制、治疗突破及专利趋势。

Unveiling Psoriasis: Delving into Pathogenesis, Treatment Breakthroughs, and Patent Trends.

作者信息

Maurya Azad Kumar, Jain Dharmendra

机构信息

Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar (M.P.), Pin Code, 470003, India.

出版信息

Recent Adv Inflamm Allergy Drug Discov. 2025;19(1):31-45. doi: 10.2174/0127722708307214240628042627.

Abstract

Over the world, millions of individuals suffer from psoriasis, a chronic inflammatory skin disease. It is caused by a multifaceted mixture of environmental, immunological, and genetic factors. This review explores the many aspects of psoriasis, where the introduction gives a context background, emphasizing the prevalence and difficulties that people encounter with this dermatological ailment. Further, the pathogenesis complex systems involving immunological dysregulation, genetic susceptibility, and triggers are clarified, providing insights into the disease's fundamental mechanisms. Examining drugs shows how, over time, therapy modalities have evolved, moving from traditional topical treatments to the introduction of biologics and small molecules. The continuous efforts to control symptoms, reduce inflammation, and improve patient outcomes are highlighted in this section. Furthermore, a thorough review of patents reveals the creative advancements made in the sector, highlighting encouraging advancements in treatment modalities and potential paths forward. This manuscript is a review article and is based on various research and review articles. We have summarized the salient features and findings from different articles and prepared this manuscript.

摘要

在全球范围内,数以百万计的人患有银屑病,这是一种慢性炎症性皮肤病。它是由环境、免疫和遗传因素的多方面混合引起的。本综述探讨了银屑病的诸多方面,引言部分给出了背景情况,强调了这种皮肤病的患病率以及患者所面临的困难。此外,还阐明了涉及免疫失调、遗传易感性和触发因素的发病机制复杂系统,从而深入了解该疾病的基本机制。对药物的研究表明,随着时间的推移,治疗方式是如何从传统的局部治疗发展到生物制剂和小分子药物的引入。本节强调了为控制症状、减轻炎症和改善患者预后所做的持续努力。此外,对专利的全面审查揭示了该领域取得的创新性进展,突出了治疗方式方面令人鼓舞的进步以及未来的潜在发展方向。本手稿是一篇综述文章,基于各种研究和综述文章撰写。我们总结了不同文章的显著特征和研究结果,并撰写了本手稿。

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