Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Obes Res Clin Pract. 2013 Jul-Aug;7(4):e269-74. doi: 10.1016/j.orcp.2012.01.002.
Experience with Roux-en-Y gastric bypass in patients with type 1 diabetes is very limited, despite an increasing prevalence of obesity also in this population. We describe changes in anthropometric measures, insulin dose, HbA1c, blood pressure, lipid status, and metabolic response to a liquid mixed meal throughout the first year after RYGB in an obese patient with type 1 diabetes. No change in HbA1c was observed, but a 48% reduction in weight-adjusted insulin dose and improvements in cardiovascular risk factors was seen 1 year after surgery. Exaggerated secretions of anorexigenic gut hormones were seen during the meals.
尽管 1 型糖尿病患者中的肥胖患病率也在不断增加，但 Roux-en-Y 胃旁路术在该人群中的应用经验非常有限。我们描述了 1 型糖尿病肥胖患者在 RYGB 后 1 年内，人体测量学指标、胰岛素剂量、HbA1c、血压、血脂状况和混合液餐代谢反应的变化。尽管 HbA1c 没有变化，但手术后体重校正胰岛素剂量减少了 48%，心血管危险因素得到改善。在进餐期间，发现了厌食性肠道激素分泌的夸大。
