N.K. Koltzov Institute of Developmental Biology, USSR Academy of Sciences, Moscow, USSR.
Theor Appl Genet. 1979 Jan;55(1):17-21. doi: 10.1007/BF00282971.
A new method is suggested for controlling species of insect pests in which the female is heterogametic. This method, involving the use of balanced lethals on the Z chromosome, causes the death of females in the embryonic stage. The method has already been tested in practical sericulture for the production of entirely male progeny of the silkworm. The method requires the construction of two strains of the pest, one carrying two balanced nonallelic but closely located lethals on the Z chromosome, and another with two other pairs of lethals of the same type. In the hybrid progeny from the crosses between the two strains, 100% of the female embryos would die, thus making it possible to release only males without any laborious procedure for sex discrimination. In the progeny from the crosses between the released males and females from the natural population, again 100% of females would die, but the males would survive and when they mated - 62.5% of the female progeny would die. This rate would decline to 34.4 and 16.6% in the sons and grandsons respectively. The repeated release of hybrid males would lead to a progressive increase, with each successive generation, in the percentage of female mortality in the natural population until its total extinction.
提出了一种新的方法来控制雌性异型配子的昆虫害虫。该方法涉及使用 Z 染色体上的平衡致死基因，导致雌性在胚胎期死亡。该方法已经在实际的养蚕生产中用于生产完全雄性蚕后代。该方法需要构建两种害虫品系，一种携带两个位于 Z 染色体上的非等位但紧密相邻的平衡致死基因，另一种携带两对相同类型的其他致死基因。在两种品系杂交的杂种后代中，100%的雌性胚胎会死亡，从而可以只释放雄性，而无需进行繁琐的性别鉴定程序。在从释放的雄性和自然种群中的雌性杂交的后代中，同样有 100%的雌性会死亡，但雄性会存活下来，当它们交配时，62.5%的雌性后代会死亡。这个比例在儿子和孙子中分别下降到 34.4%和 16.6%。反复释放杂交雄性会导致自然种群中雌性死亡率的比例逐代增加，直到其完全灭绝。
