1Department of Pathology, Mansoura University, Egypt.
Lupus. 2014 Feb;23(2):146-50. doi: 10.1177/0961203313514125. Epub 2013 Dec 4.
Podocyte damage is an important pathogenic component of glomerular disease progression. This study is a trial to clarify the value of counting and scoring the number of shed Bowman's space podocytes as an activity parameter of lupus nephritis, a trial that has not been conducted before. This study was performed on 42 female patients with the clinical diagnosis of lupus nephritis. Beside the routine stains tissue sections were stained by colloidal iron and anti podocalyxin for sialomucin. Podocytes in the Bowman's space were counted and scored. Thorough statistical work was carried out to correlate the podocyte scores with the morphological lesions of lupus nephritis. This study revealed significant association and correlation of shed Bowman's space podocytes with histopathological parameters of activity in different classes of lupus nephritis. We concluded that counting and scoring shed Bowman's space podocytes is statistically significant as a marker of disease activity in lupus nephritis. It can be one of the parameters of activity index but not of chronicity index.
足细胞损伤是肾小球疾病进展的重要致病因素。本研究旨在阐明计数和评分脱落的鲍曼氏囊足细胞数量作为狼疮性肾炎活动参数的价值，这是一项以前未曾进行过的研究。本研究共纳入 42 名临床诊断为狼疮性肾炎的女性患者。除了常规染色外，还对组织切片进行胶体铁和抗 podocalyxin 染色，以检测唾液黏蛋白。对鲍曼氏囊中的足细胞进行计数和评分。对足细胞评分与狼疮性肾炎的形态学病变进行了深入的统计学分析。本研究显示，脱落的鲍曼氏囊足细胞与不同类型狼疮性肾炎的活动组织病理学参数之间存在显著的关联和相关性。我们得出结论，计数和评分脱落的鲍曼氏囊足细胞是狼疮性肾炎疾病活动的一个有统计学意义的标志物。它可以作为活动指数的参数之一，但不是慢性指数的参数。
