Spencer S E, Talman W T
Brain Res. 1986 Oct 22;385(2):371-4. doi: 10.1016/0006-8993(86)91085-1.
We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As previously reported, L-glu and ACh, but not SP elicited dose-dependent arterial hypotension. The data support a putative role for SP in visceral reflexes mediated by vagal nerves.
我们试图确定在对背内侧孤束核进行选择性化学刺激时，动脉压和胃内压是否会发生变化。P物质（SP）和L-谷氨酸（L-glu），而非乙酰胆碱（ACh），可引起胃张力性压力呈剂量依赖性降低，并抑制胃的相性活动。如先前报道，L-谷氨酸和乙酰胆碱可引起剂量依赖性动脉低血压，而P物质则不会。这些数据支持P物质在迷走神经介导的内脏反射中可能发挥的作用。
