Liskowsky D R, Norenberg L O, Norenberg M D
Brain Res. 1986 Oct 29;386(1-2):386-8. doi: 10.1016/0006-8993(86)90176-9.
Exposure of primary astrocyte cultures to ammonia caused a dose- and time-dependent reduction of isoproterenol-stimulated cyclic AMP (cAMP) production. This treatment did not affect basal cAMP levels. This defect in receptor-linked cAMP production may contribute to the pathogenesis of hepatic and ammonia encephalopathies.
将原代星形胶质细胞培养物暴露于氨中会导致异丙肾上腺素刺激的环磷酸腺苷（cAMP）生成量呈剂量和时间依赖性减少。这种处理不影响基础cAMP水平。受体相关的cAMP生成缺陷可能促成肝性和氨性脑病的发病机制。
