Gregorios J B, Mozes L W, Norenberg L O, Norenberg M D
J Neuropathol Exp Neurol. 1986 Jul;45(4):396-407. doi: 10.1097/00005072-198607000-00002.
Current evidence suggests that astrocytes may be the target of ammonia toxicity. Consistent with this view are recent investigations which have shown morphologic alterations in primary astrocyte cultures following exposure to ammonia. In the present study, these alterations became severely aggravated when the cultures were not grown or maintained in dibutyryl cyclic adenosine monophosphate (AMP). Cyclic AMP analogues and agents that increase intracellular cyclic AMP levels significantly inhibited the toxic effects of ammonia. The exact mechanism responsible for this apparent protective effect of cyclic AMP on ammonia-treated astrocytes is not known. The possible means by which cyclic AMP may serve to ameliorate ammonia-induced toxicity are discussed.
目前的证据表明，星形胶质细胞可能是氨毒性的靶点。近期研究与这一观点相符，这些研究表明，原代星形胶质细胞培养物在暴露于氨后出现了形态学改变。在本研究中，当培养物未在二丁酰环磷酸腺苷（cAMP）中生长或维持时，这些改变会严重加剧。环磷酸腺苷类似物和能提高细胞内环磷酸腺苷水平的药物可显著抑制氨的毒性作用。环磷酸腺苷对氨处理的星形胶质细胞产生这种明显保护作用的确切机制尚不清楚。本文讨论了环磷酸腺苷可能用于改善氨诱导毒性的可能方式。
