Gershenson D M, Wharton J T, Kline R C, Larson D M, Kavanagh J J, Rutledge F N
Cancer. 1986 Dec 15;58(12):2594-9. doi: 10.1002/1097-0142(19861215)58:12<2594::aid-cncr2820581207>3.0.co;2-z.
Two patients with metastatic dysgerminoma of the ovary were treated with a combination of etoposide, bleomycin, and cisplatin at The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston. Both patients achieved a complete remission. Patient 1 developed a massive recurrence in the para-aortic lymph nodes 21 months after diagnosis and treatment with right salpingo-oophorectomy alone. She received four cycles of chemotherapy and is free of disease 21 months from the start of chemotherapy. Patient 2 had Stage III dysgerminoma and a lymphangiogram positive for tumor in the para-aortic lymph nodes. After surgery she received three cycles of chemotherapy and is free of disease 20 months from the start of chemotherapy. Both complete remissions were documented with second-look laparotomy. Chemotherapy may be an alternative to radiotherapy for the treatment of metastatic dysgerminoma and should also be considered for selected patients with Stage I disease. A literature review further supports the conclusion that additional clinical trials might expand the indications for chemotherapy in patients with this disease.
两名卵巢转移性无性细胞瘤患者在休斯顿的德克萨斯大学MD安德森癌症中心接受了依托泊苷、博来霉素和顺铂联合治疗。两名患者均实现了完全缓解。患者1在仅接受右侧输卵管卵巢切除术诊断和治疗21个月后，腹主动脉旁淋巴结出现大量复发。她接受了四个周期的化疗，从化疗开始21个月后无疾病迹象。患者2患有III期无性细胞瘤，淋巴管造影显示腹主动脉旁淋巴结有肿瘤。手术后，她接受了三个周期的化疗，从化疗开始20个月后无疾病迹象。两次完全缓解均通过二次剖腹探查得到证实。化疗可能是转移性无性细胞瘤放疗的替代治疗方法，对于部分I期疾病患者也应考虑使用。文献综述进一步支持以下结论：更多的临床试验可能会扩大这种疾病患者化疗的适应症。
