Williams S D, Blessing J A, Hatch K D, Homesley H D
Department of Medicine, Indiana University, Indianapolis.
J Clin Oncol. 1991 Nov;9(11):1950-5. doi: 10.1200/JCO.1991.9.11.1950.
Between 1984 and 1989, 20 assessable patients with incompletely resected ovarian dysgerminoma were treated on two protocols of the Gynecologic Oncology Group (GOG). All patients received cisplatin, bleomycin, and either vinblastine or etoposide. More recent patients also received consolidation chemotherapy with vincristine, dactinomycin, and cyclophosphamide (VAC). Eleven patients had clinically measurable disease, and 10 responded completely. Fourteen second-look procedures were done, and all were negative. Currently, 19 of 20 patients are disease-free with median follow-up of 26 months. Cisplatin-based chemotherapy is highly effective in patients with advanced dysgerminoma.
1984年至1989年间，20例可评估的卵巢无性细胞瘤切除不完全的患者接受了妇科肿瘤学组（GOG）的两项治疗方案。所有患者均接受顺铂、博来霉素以及长春花碱或依托泊苷治疗。近期的患者还接受了长春新碱、放线菌素D和环磷酰胺（VAC）的巩固化疗。11例患者有临床可测量的疾病，10例完全缓解。进行了14次二次探查手术，结果均为阴性。目前，20例患者中有19例无疾病，中位随访时间为26个月。以顺铂为基础的化疗对晚期无性细胞瘤患者非常有效。
