Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7 (France).
Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14103-7. doi: 10.1002/anie.201308873. Epub 2013 Dec 4.
A low-cost, modular, and easily scalable multicomponent procedure affording access in good yields and excellent selectivity (up to 93%) to a wide range of (a)chiral unsymmetrical 1-aryl-3-cycloalkyl-imidazolium salts is disclosed. Electronic and steric properties of the corresponding unsymmetrical unsaturated N-heterocyclic carbene (U2-NHC) ligands were evaluated and evidenced strong electron donor ability, high steric discrimination, and modular steric demand.
本文公开了一种低成本、模块化且易于扩展的多组分方法，该方法以良好的收率和出色的选择性（高达 93%），提供了广泛的（a）手性不对称 1-芳基-3-环烷基-咪唑鎓盐。评估了相应的不对称不饱和 N-杂环卡宾（U2-NHC）配体的电子和空间性质，并证明了其具有很强的电子给体能力、高空间位阻选择性和模块化空间位阻需求。
