易于获得的不对称不饱和 2,6-二异丙基苯基 N-杂环卡宾配体。在手性催化中的应用。
Readily Accessible Unsymmetrical Unsaturated 2,6-Diisopropylphenyl N-Heterocyclic Carbene Ligands. Applications in Enantioselective Catalysis.
机构信息
Ecole Nationale Supérieure de Chimie de Rennes, CNRS UMR 6226, Institut des Sciences Chimiques de Rennes , 11 Allée de Beaulieu, Rennes 35708 Cedex 7, France.
Université de Rennes 1, CNRS, UMR 6226, Institut des Sciences Chimiques de Rennes , Centre de Diffractométrie X, Bat 10B, Campus de Beaulieu, Rennes Cedex 35042, France.
出版信息
J Org Chem. 2017 Feb 17;82(4):1880-1887. doi: 10.1021/acs.joc.6b02888. Epub 2017 Feb 2.
A new multicomponent procedure was applied to the synthesis of (a)chiral bulky unsymmetrical unsaturated 2,6-diisopropylphenyl N-heterocyclic carbene (NHC) precursors with excellent selectivity (up to 95%) and good yields. This approach offers access to new chiral NHC ligands, which have found successful applications in both copper-catalyzed asymmetric allylic alkylation and copper-catalyzed asymmetric borylation.
一种新的多组分方法被应用于（a）手性大位阻不对称不饱和 2,6-二异丙基苯基 N-杂环卡宾（NHC）前体的合成，具有优异的选择性（高达 95%）和良好的收率。这种方法提供了获得新的手性 NHC 配体的途径，这些配体已成功应用于铜催化的不对称烯丙基烷基化和铜催化的不对称硼化反应中。
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