Blomberg Björn A, Thomassen Anders, Takx Richard A P, Vilstrup Mie H, Hess Søren, Nielsen Anne L, Diederichsen Axel C P, Mickley Hans, Alavi Abass, Høilund-Carlsen Poul F
Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark,
J Nucl Cardiol. 2014 Apr;21(2):293-304. doi: 10.1007/s12350-013-9829-5. Epub 2013 Dec 5.
This study aimed to determine if delayed sodium (18)F-fluoride (Na(18)F) PET/CT imaging improves quantification of vascular calcification metabolism. Blood-pool activity can disturb the arterial Na(18)F signal. With time, blood-pool activity declines. Therefore, delayed imaging can potentially improve quantification of vascular calcification metabolism.
Twenty healthy volunteers and 18 patients with chest pain were prospectively assessed by triple time-point PET/CT imaging at approximately 45, 90, and 180 minutes after Na(18)F administration. For each time point, global uptake of Na(18)F was determined in the coronary arteries and thoracic aorta by calculating the blood-pool-corrected maximum standardized uptake value (cSUV(MAX)). A target-to-background ratio (TBR) was calculated to determine the contrast resolution at 45, 90, and 180 minutes. Furthermore, we assessed whether the acquisition time-point affected the relation between cSUV(MAX) and the estimated 10-year risk for fatal cardiovascular disease (SCORE %). Coronary cSUV(MAX) (P = .533) and aortic cSUV(MAX) (P = .654) remained similar with time, whereas the coronary TBR (P < .0001) and aortic TBR (P < .0001) significantly increased with time. Even though the contrast resolution improved with time, positive correlations between SCORE % and coronary cSUV(MAX) (P < .020) and aortic cSUV(MAX) (P < .005) were observed at all investigated time points.
Delayed Na(18)F PET/CT imaging does not improve quantification of vascular calcification metabolism. Although contrast resolution improves with time, arterial Na(18)F avidity is invariant to the time between Na(18)F administration and PET/CT acquisition. Therefore, the optimal PET/CT acquisition time-point to quantify vascular calcification metabolism is achieved as early as 45 minutes after Na(18)F administration.
本研究旨在确定延迟的钠[¹⁸F]氟化物（Na[¹⁸F]）PET/CT成像是否能改善血管钙化代谢的定量分析。血池活性会干扰动脉Na[¹⁸F]信号。随着时间推移，血池活性会下降。因此，延迟成像可能会改善血管钙化代谢的定量分析。
20名健康志愿者和18名胸痛患者在注射Na[¹⁸F]后约45、90和180分钟接受了三次时间点的PET/CT成像前瞻性评估。对于每个时间点，通过计算校正血池后的最大标准化摄取值（cSUV(MAX)）来确定冠状动脉和胸主动脉中Na[¹⁸F]的整体摄取情况。计算目标与背景比值（TBR）以确定在45、90和180分钟时的对比分辨率。此外，我们评估了采集时间点是否会影响cSUV(MAX)与估计的10年致命心血管疾病风险（SCORE%）之间的关系。冠状动脉cSUV(MAX)（P = 0.533）和主动脉cSUV(MAX)（P = 0.654）随时间保持相似，而冠状动脉TBR（P < 0.0001）和主动脉TBR（P < 0.0001）随时间显著增加。尽管对比分辨率随时间提高，但在所有研究时间点均观察到SCORE%与冠状动脉cSUV(MAX)（P < 0.020）和主动脉cSUV(MAX)（P < 0.005）之间存在正相关。
延迟的Na[¹⁸F]PET/CT成像并不能改善血管钙化代谢的定量分析。尽管对比分辨率随时间提高，但动脉对Na[¹⁸F]的摄取在注射Na[¹⁸F]与PET/CT采集之间的时间内是不变的。因此，在注射Na[¹⁸F]后最早45分钟即可实现定量血管钙化代谢的最佳PET/CT采集时间点。
