Amabile G, Fattapposta F, Pozzessere G, Albani G, Sanarelli L, Rizzo P A, Morocutti C
Electroencephalogr Clin Neurophysiol. 1986 Dec;64(6):521-4. doi: 10.1016/0013-4694(86)90189-6.
The contingent negative variation (CNV) was studied in a group of patients with Parkinson's disease. Testing was carried out 3 times: after a pharmacological wash-out period and at 15 and 30 days after the start of treatment with L-DOPA and bromocriptine. Peak and area CNV increased significantly after each treatment. The post-imperative negative variation (PINV) was observed in 6 out of 10 patients. The correlation found between electrophysiological functioning (CNV) measures and pharmacological treatment supports the view that dopaminergic brain activity mediates the generation of the slow negative event-related brain potentials.
