Rumbach L, Tranchant C, Viel J F, Warter J M
Service de Neurologie, CHU Jean Minjoz, Besançon, France.
J Neurol Sci. 1993 Jun;116(2):148-51. doi: 10.1016/0022-510x(93)90319-t.
Auditory event-related potentials were recorded using the oddball paradigm in 26 patients with Parkinson's disease, all treated with L-Dopa. The latency of the P3 wave was significantly greater than in an age-matched controls, and was also correlated with the disease duration, but not with scores on two scales measuring cognitive deficit. One year later, when treatment with a dopaminergic agonist, bromocriptine 20-30 mg/day, had been added to the therapeutic regimen, N2 and P3 latencies had increased, whereas several clinical parameters had improved. Thus a longer P3 latency does not seem to be linked to a global cognitive deficit. The use of neuropsychological tests exploring more limited tasks should show the prospective utility of event-related potentials in Parkinson's disease.
使用oddball范式对26例均接受左旋多巴治疗的帕金森病患者记录听觉事件相关电位。P3波潜伏期显著长于年龄匹配的对照组，且与病程相关，但与两项测量认知缺陷的量表得分无关。一年后，当治疗方案中加入多巴胺能激动剂溴隐亭（20 - 30毫克/天）时，N2和P3潜伏期增加，而多项临床参数有所改善。因此，较长的P3潜伏期似乎与整体认知缺陷无关。采用探索更有限任务的神经心理学测试应能显示事件相关电位在帕金森病中的潜在效用。
